The impact of glutathione transferase kappa deficiency on adiponectin multimerisation in vivo
dc.contributor.author | Theodoratos, Angelo | |
dc.contributor.author | Blackburn, Anneke | |
dc.contributor.author | Coggan, Marjorie | |
dc.contributor.author | Cappello, Jean | |
dc.contributor.author | Larter, Claire | |
dc.contributor.author | Matthaei, Klaus | |
dc.contributor.author | Board, Philip | |
dc.date.accessioned | 2015-12-10T22:27:30Z | |
dc.date.issued | 2012 | |
dc.date.updated | 2015-12-09T09:41:22Z | |
dc.description.abstract | Glutathione transferase Kappa (GSTK1-1) also termed disulfide bond-forming oxidoreductase A-like protein (DsbA-L) has been implicated in the post-translational multimerization of adiponectin and has been negatively correlated with obesity in mice and humans. We investigated adiponectin in Gstk1-/- mice and surprisingly found no difference in the levels of total serum adiponectin or the level of high molecular weight (HMW) multimers when compared with normal controls. Non-reducing SDS-polyacrylamide gel electrophoresis and western blotting also showed a similar distribution of low, middle and HMW multimers in normal and Gstk1-/- mice. Variation in adiponectin has been correlated with glucose tolerance and with the levels of phosphorylated AMP-kinase but we found similar glucose tolerance and similar levels of phospho 5-AMP-activated protein kinase in normal and Gstk1-/- mice. Consequently, our findings suggest that GSTK1-1 is not absolutely required for adiponectin multimerization in vivo and alternate pathways may be activated in GSTK1-1 deficiency.International Journal of Obesity advance online publication, 17 January 2012; doi:10.1038/ijo.2011.267. | |
dc.identifier.issn | 0307-0565 | |
dc.identifier.uri | http://hdl.handle.net/1885/54237 | |
dc.publisher | Nature Publishing Group | |
dc.source | International Journal of Obesity | |
dc.title | The impact of glutathione transferase kappa deficiency on adiponectin multimerisation in vivo | |
dc.type | Journal article | |
local.bibliographicCitation.issue | 3 | |
local.bibliographicCitation.lastpage | 33 | |
local.bibliographicCitation.startpage | 427 | |
local.contributor.affiliation | Theodoratos, Angelo, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Blackburn, Anneke, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Coggan, Marjorie, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Cappello, Jean, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Larter, Claire, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Matthaei, Klaus, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Board, Philip, College of Medicine, Biology and Environment, ANU | |
local.contributor.authoremail | u4036935@anu.edu.au | |
local.contributor.authoruid | Theodoratos, Angelo, u4036935 | |
local.contributor.authoruid | Blackburn, Anneke, u4048450 | |
local.contributor.authoruid | Coggan, Marjorie, u7400157 | |
local.contributor.authoruid | Cappello, Jean, u9601131 | |
local.contributor.authoruid | Larter, Claire, u4367140 | |
local.contributor.authoruid | Matthaei, Klaus, u8200697 | |
local.contributor.authoruid | Board, Philip, u7701651 | |
local.description.embargo | 2037-12-31 | |
local.description.notes | Imported from ARIES | |
local.identifier.absfor | 110107 - Metabolic Medicine | |
local.identifier.ariespublication | u4020362xPUB295 | |
local.identifier.citationvolume | 83 | |
local.identifier.doi | 10.1038/ijo.2011.267 | |
local.identifier.scopusID | 2-s2.0-84855820608 | |
local.identifier.thomsonID | 000309649400018 | |
local.identifier.uidSubmittedBy | u4020362 | |
local.type.status | Published Version |
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