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Item type: Publication , Access status: Open Access , In vivo metabolism of the designer anabolic steroid hemapolin in the thoroughbred horse(Wiley, 2020-01-16)Hemapolin (2α,3α-epithio-17α-methyl-5α-androstan-17β-ol) is a designer steroid that is an ingredient in several “dietary” and “nutritional” supplements available online. As an unusual chemical modification to the steroid A-ring could allow this compound to pass through antidoping screens undetected, the metabolism of hemapolin was investigated by an in vivo equine drug administration study coupled with GC-MS analysis. Following administration of synthetically prepared hemapolin to a thoroughbred horse, madol (17α-methyl-5α-androst-2-en-17β-ol), reduced and dihydroxylated madol (17α-methyl-5α-androstane-2β,3α,17β-triol), and the isomeric enone metabolites 17β-hydroxy-17α-methyl-5α-androst-3-en-2-one and 17β-hydroxy-17α-methyl5α-androst-2-en-4-one, were detected and confirmed in equine urine extracts by comparison with a library of synthetically derived reference materials. A number of additional madol derivatives derived from hydroxylation, dihydroxylation, and trihydroxylation were also detected but not fully identified by this approach. A yeast cell-based androgen receptor bioassay of available reference materials showed that hemapolin and many of the metabolites identified by this study were potent activators of the equine androgen receptor. This study reveals the metabolites resulting from the equine administration of the androgen hemapolin that can be incorporated into routine GC-MS antidoping screening and confirmation protocols to detect the illicit use of this agent in equine sports.Item type: Item , Access status: Restricted , Commonwealth administrative tribunals.(1969-12) Commonwealth administrative tribunals.The twentieth century has witnessed many remarkable developments, but one of the most noteworthy is the extent to vhich society has become more complex and organisedItem type: Item , Access status: Open Access , Condoman: 1 x 10-second radio commercial(1994) Noel Butlin Archives Centre (1953-); Department of Community Services and HealthItem type: Item , Access status: Open Access , National Gay and Bisexual Campaign by the Department of Community Services and Health: 3 x 30 second radio commercials(1992) Noel Butlin Archives Centre (1953-); Australian National Council on AIDS; Department of Community Services and Health1. Gay men -- 2. Bisexual men -- 3. Relationships.Item type: Item , Access status: Open Access , Rushes for Senior Australian of the Year 2007: Phil Herreen, Christopher Pyne, aqua classes, elderly woman with child, bowls, caféNoel Butlin Archives Centre (1953-); Department of Health and AgeingRecorded 21 and 23 September 2007.