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MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

Date

Authors

Humphreys, David T

Westman, Belinda J

Martin, David I K

Preiss, Thomas

Publisher

National Academy of Sciences (USA)

Abstract

MicroRNAs (miRNAs) repress translation of target mRNAs by interaction with partially mismatched sequences in their 3′ UTR. The mechanism by which they act on translation has remained largely obscure. We examined the translation of mRNAs containing four

Keywords

Keywords: capped RNA; initiation factor 4E; messenger RNA; microRNA; polyadenylic acid; small interfering RNA; 3' untranslated region; article; binding site; controlled study; cricket paralysis virus; Encephalomyocarditis virus; genetic transfection; HeLa cell; hum Cap structure; mRNA decay; mRNA translation; Processing bodies; Short interfering RNA

URI

http://hdl.handle.net/1885/52622

Collections

ANU Research Publications

Source

PNAS - Proceedings of the National Academy of Sciences of the United States of America

Type

Journal article

DOI

10.1073/pnas.0506482102

Restricted until

2037-12-31

Downloads

File

Description

01_Humphreys_MicroRNAs_control_translation_2005.pdf (381.52 KB)