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MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

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dc.contributor.authorHumphreys, David T
dc.contributor.authorWestman, Belinda J
dc.contributor.authorMartin, David I K
dc.contributor.authorPreiss, Thomas
dc.date.accessioned2015-12-10T22:22:19Z
dc.date.issued2005
dc.date.updated2015-12-09T09:02:39Z
dc.description.abstractMicroRNAs (miRNAs) repress translation of target mRNAs by interaction with partially mismatched sequences in their 3′ UTR. The mechanism by which they act on translation has remained largely obscure. We examined the translation of mRNAs containing four
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/1885/52622
dc.publisherNational Academy of Sciences (USA)
dc.sourcePNAS - Proceedings of the National Academy of Sciences of the United States of America
dc.subjectKeywords: capped RNA; initiation factor 4E; messenger RNA; microRNA; polyadenylic acid; small interfering RNA; 3' untranslated region; article; binding site; controlled study; cricket paralysis virus; Encephalomyocarditis virus; genetic transfection; HeLa cell; hum Cap structure; mRNA decay; mRNA translation; Processing bodies; Short interfering RNA
dc.titleMicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function
dc.typeJournal article
local.bibliographicCitation.issue47
local.bibliographicCitation.lastpage6
local.bibliographicCitation.startpage16961
local.contributor.affiliationHumphreys, David T, Victor Chang Chardiac Research Institute
local.contributor.affiliationWestman, Belinda J, Victor Chang Cardiac Research Institute
local.contributor.affiliationMartin, David I K, Children's Hospital Oakland Institute
local.contributor.affiliationPreiss, Thomas, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidPreiss, Thomas, u5046545
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060405 - Gene Expression (incl. Microarray and other genome-wide approaches)
local.identifier.absfor111203 - Cancer Genetics
local.identifier.ariespublicationu4020362xPUB251
local.identifier.citationvolume102
local.identifier.doi10.1073/pnas.0506482102
local.identifier.scopusID2-s2.0-28044457883
local.type.statusPublished Version

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