Decreased Threshold for the Nitric Oxide Donor Glyceryl Trinitrate in Cortisol-Induced Hypertension in Humans
Date
2007
Authors
Kelly, John J
Tam, Sim Hom
Williamson, Paula M
Whitworth, Judith
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Blackwell Science Asia
Abstract
1. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.
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Keywords
Keywords: glyceryl trinitrate; hydrocortisone; nitric oxide donor; adult; article; blood pressure monitoring; clinical article; controlled study; human; hypertension; male; mean arterial pressure; pressoreceptor reflex; systolic blood pressure; Adult; Blood Pressur Blood pressure; Cortisol; Glucocorticoids; Glyceryl trinitrate; Humans; Nitric oxide
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Source
Clinical and Experimental Pharmacology and Physiology
Type
Journal article
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2037-12-31
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