Decreased Threshold for the Nitric Oxide Donor Glyceryl Trinitrate in Cortisol-Induced Hypertension in Humans

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dc.contributor.authorKelly, John J
dc.contributor.authorTam, Sim Hom
dc.contributor.authorWilliamson, Paula M
dc.contributor.authorWhitworth, Judith
dc.date.accessioned2015-12-07T22:25:15Z
dc.date.issued2007
dc.date.updated2015-12-07T09:33:58Z
dc.description.abstract1. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.
dc.identifier.issn0305-1870
dc.identifier.urihttp://hdl.handle.net/1885/21185
dc.publisherBlackwell Science Asia
dc.sourceClinical and Experimental Pharmacology and Physiology
dc.subjectKeywords: glyceryl trinitrate; hydrocortisone; nitric oxide donor; adult; article; blood pressure monitoring; clinical article; controlled study; human; hypertension; male; mean arterial pressure; pressoreceptor reflex; systolic blood pressure; Adult; Blood Pressur Blood pressure; Cortisol; Glucocorticoids; Glyceryl trinitrate; Humans; Nitric oxide
dc.titleDecreased Threshold for the Nitric Oxide Donor Glyceryl Trinitrate in Cortisol-Induced Hypertension in Humans
dc.typeJournal article
local.bibliographicCitation.lastpage1318
local.bibliographicCitation.startpage1317
local.contributor.affiliationKelly, John J, University of New South Wales
local.contributor.affiliationTam, Sim Hom, University of New South Wales
local.contributor.affiliationWilliamson, Paula M, University of New South Wales
local.contributor.affiliationWhitworth, Judith, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu9910403@anu.edu.au
local.contributor.authoruidWhitworth, Judith, u9910403
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110201 - Cardiology (incl. Cardiovascular Diseases)
local.identifier.ariespublicationu9505948xPUB15
local.identifier.citationvolume34
local.identifier.doi10.1111/j.1440-1681.2007.04700.x
local.identifier.scopusID2-s2.0-35548984891
local.identifier.uidSubmittedByu9505948
local.type.statusPublished Version

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