Decreased Threshold for the Nitric Oxide Donor Glyceryl Trinitrate in Cortisol-Induced Hypertension in Humans
dc.contributor.author | Kelly, John J | |
dc.contributor.author | Tam, Sim Hom | |
dc.contributor.author | Williamson, Paula M | |
dc.contributor.author | Whitworth, Judith | |
dc.date.accessioned | 2015-12-07T22:25:15Z | |
dc.date.issued | 2007 | |
dc.date.updated | 2015-12-07T09:33:58Z | |
dc.description.abstract | 1. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability. | |
dc.identifier.issn | 0305-1870 | |
dc.identifier.uri | http://hdl.handle.net/1885/21185 | |
dc.publisher | Blackwell Science Asia | |
dc.source | Clinical and Experimental Pharmacology and Physiology | |
dc.subject | Keywords: glyceryl trinitrate; hydrocortisone; nitric oxide donor; adult; article; blood pressure monitoring; clinical article; controlled study; human; hypertension; male; mean arterial pressure; pressoreceptor reflex; systolic blood pressure; Adult; Blood Pressur Blood pressure; Cortisol; Glucocorticoids; Glyceryl trinitrate; Humans; Nitric oxide | |
dc.title | Decreased Threshold for the Nitric Oxide Donor Glyceryl Trinitrate in Cortisol-Induced Hypertension in Humans | |
dc.type | Journal article | |
local.bibliographicCitation.lastpage | 1318 | |
local.bibliographicCitation.startpage | 1317 | |
local.contributor.affiliation | Kelly, John J, University of New South Wales | |
local.contributor.affiliation | Tam, Sim Hom, University of New South Wales | |
local.contributor.affiliation | Williamson, Paula M, University of New South Wales | |
local.contributor.affiliation | Whitworth, Judith, College of Medicine, Biology and Environment, ANU | |
local.contributor.authoremail | u9910403@anu.edu.au | |
local.contributor.authoruid | Whitworth, Judith, u9910403 | |
local.description.embargo | 2037-12-31 | |
local.description.notes | Imported from ARIES | |
local.identifier.absfor | 110201 - Cardiology (incl. Cardiovascular Diseases) | |
local.identifier.ariespublication | u9505948xPUB15 | |
local.identifier.citationvolume | 34 | |
local.identifier.doi | 10.1111/j.1440-1681.2007.04700.x | |
local.identifier.scopusID | 2-s2.0-35548984891 | |
local.identifier.uidSubmittedBy | u9505948 | |
local.type.status | Published Version |
Downloads
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- 01_Kelly_Decreased_Threshold_for_the_2007.pdf
- Size:
- 55.75 KB
- Format:
- Adobe Portable Document Format