Dengue virus M protein C-terminal peptide (DVM-C) forms ion channels

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dc.contributor.authorPremkumar, Anita
dc.contributor.authorHoran, Catherine
dc.contributor.authorGage, Peter
dc.date.accessioned2015-12-13T22:27:20Z
dc.date.issued2005
dc.date.updated2015-12-11T08:30:37Z
dc.description.abstractA chemically synthesized peptide consisting of the C-terminus of the M protein of the Dengue virus type 1 strain Singapore S275/90 (DVM-C) produced ion channel activity in artificial lipid bilayers. The channels had a variable conductance and were more permeable to sodium and potassium ions than to chloride ions and more permeable to chloride ions than to calcium ions. Hexamethylene amiloride (100 μM) and amantadine (10 μM), blocked channels formed by DVM-C. Ion channels may play an important role in the life cycle of many viruses and drugs that block these channels may prove to be useful antiviral agents.
dc.identifier.issn0022-2631
dc.identifier.urihttp://hdl.handle.net/1885/73901
dc.publisherSpringer
dc.sourceJournal of Membrane Biology
dc.subjectKeywords: amantadine; amiloride; cyclohexane; ion channel; M protein; peptide; virus protein; article; calcium conductance; carboxy terminal sequence; cell membrane permeability; channel gating; chloride conductance; controlled study; Dengue virus; HeLa cell; human Amantadine; Dengue; DVM-C; HMA; Virus ion channels
dc.titleDengue virus M protein C-terminal peptide (DVM-C) forms ion channels
dc.typeJournal article
local.bibliographicCitation.lastpage38
local.bibliographicCitation.startpage33
local.contributor.affiliationPremkumar, Anita, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHoran, Catherine, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGage, Peter, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidPremkumar, Anita, u3803398
local.contributor.authoruidHoran, Catherine, u3224060
local.contributor.authoruidGage, Peter, u8404889
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.ariespublicationMigratedxPub3880
local.identifier.citationvolume204
local.identifier.doi10.1007/s00232-005-0744-9
local.identifier.scopusID2-s2.0-22044441322
local.type.statusPublished Version

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