A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration
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Authors
Chu, Jessie
Hong, Nancy A
Masuda, Claudio A.
Jenkins, Brian V.
Nelms, Keats
Goodnow, Christopher
Glynne, Richard
Wu, Hua
Masliah, Eliezer
Joazeiro, Claudio A.P.
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National Academy of Sciences (USA)
Abstract
A mouse neurological mutant, lister, was identified through a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Homozygous lister mice exhibit profound early-onset and progressive neurological and motor dysfunction. lister encodes a RING finger
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PNAS - Proceedings of the National Academy of Sciences of the United States of America
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2037-12-31
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