Cardiovascular consequences of cortisol excess

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dc.contributor.authorWhitworth, Judith A
dc.contributor.authorWilliamson, Paula M
dc.contributor.authorMangos, George
dc.contributor.authorKelly, John J
dc.date.accessioned2016-01-27T00:39:41Z
dc.date.available2016-01-27T00:39:41Z
dc.date.issued2005-12
dc.date.updated2016-02-24T09:46:51Z
dc.description.abstractCushing's syndrome is a consequence of primary or, more commonly, secondary oversecretion of cortisol. Cardiovascular disease is the major cause of morbidity and mortality in Cushing's syndrome, and excess risk remains even in effectively treated patients. The cardiovascular consequences of cortisol excess are protean and include, inter alia, elevation of blood pressure, truncal obesity, hyperinsulinemia, hyperglycemia, insulin resistance, and dyslipidemia. This review analyses the relationship of cortisol excess, both locally and at tissue level, to these cardiovascular risk factors, and to putative mechanisms for hypertension. Previous studies have examined correlations between cortisol, blood pressure, and other parameters in the general population and in Cushing's syndrome. This review also details changes induced by short-term cortisol administration in normotensive healthy men.
dc.identifier.issn1176-6344en_AU
dc.identifier.urihttp://hdl.handle.net/1885/95663
dc.publisherDove Medical Press Ltd
dc.rights© 2005 Dove Medical Press Limited. http://www.sherpa.ac.uk/romeo/issn/1176-6344..."Publisher's version/PDF may be used. On institutional repository, central repository or subject -based repository, including PubMed Central" from SHERPA/RoMEO site (as at 27/01/16).
dc.sourceVascular Health and Risk Management
dc.subjectblood pressure
dc.subjectcortisol
dc.subjectCushing's syndrome
dc.subjectrisk factors
dc.titleCardiovascular consequences of cortisol excess
dc.typeJournal article
local.bibliographicCitation.issue4en_AU
local.bibliographicCitation.lastpage299en_AU
local.bibliographicCitation.startpage291en_AU
local.contributor.affiliationWhitworth, Judith, College of Medicine, Biology and Environment, CMBE John Curtin School of Medical Research, JCSMR General, The Australian National Universityen_AU
local.contributor.affiliationWilliamson, Paula, College of Medicine, Biology and Environment, CMBE John Curtin School of Medical Research, JCSMR General, The Australian National Universityen_AU
local.contributor.affiliationMangos, George, University of New South Wales, Australiaen_AU
local.contributor.affiliationKelly, John, Woodside Energy Ltd, Australiaen_AU
local.contributor.authoremailjudith.whitworth@anu.edu.auen_AU
local.contributor.authoruidu9910403en_AU
local.description.notesImported from ARIESen_AU
local.description.refereedYes
local.identifier.absfor110201en_AU
local.identifier.ariespublicationMigratedxPub11450en_AU
local.identifier.citationvolume1en_AU
local.identifier.doi10.2147/vhrm.2005.1.4.291en_AU
local.identifier.scopusID2-s2.0-33847128120
local.identifier.uidSubmittedByu3488905en_AU
local.publisher.urlhttps://www.dovepress.com/en_AU
local.type.statusPublished Versionen_AU

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