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Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response

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dc.contributor.authorMellor, Howard R.
dc.contributor.authorCallaghan, Richard
dc.date.accessioned2015-12-13T22:17:37Z
dc.date.issued2008
dc.date.updated2015-12-11T07:35:33Z
dc.description.abstractInherent and acquired resistance pathways account for the high rate of failure in cancer chemotherapy. The mechanisms or pathways mediating resistance may be classified as pharmacokinetic (i.e. alter intratumour drug exposue) or pharmacodynamic (i.e. failure to elicit cytotoxicity). More often than not, the resistant phenotype is characterised by alterations in multiple pathways. Consequently, the pathways may act synergistically or generate a broad spectrum of resistance to anticancer drugs. There has been a great deal of systematic characterisation of drug resistance in vitro. However, translating this greater understanding into clinical efficacy has rarely been achieved. This review explores the phenomenon of drug resistance in cancer and highlights the gap between in vitro and in vivo observations. This gap presents a major obstacle in overcoming drug resistance and restoring sensitivity to chemotherapy.
dc.identifier.issn0031-7012
dc.identifier.urihttp://hdl.handle.net/1885/71240
dc.publisherS. Karger AG
dc.sourcePharmacology
dc.subjectKeywords: anthracycline; bleomycin; carboplatin; carmustine; cisplatin; cyclophosphamide; daunorubicin; dj 927; docetaxel; doxorubicin; elacridar; epirubicin; fluorouracil; gemcitabine; hycamptin; idarubicin; ifosfamide; irinotecan; lomeguatrib; methotrexate; mitom Anticancer drugs; Cancer chemotherapy; Drug resistance; Multidrug resistance; Pharmacodynamic resistance; Pharmacokinetic resistance
dc.titleResistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response
dc.typeJournal article
local.bibliographicCitation.issue4
local.bibliographicCitation.lastpage300
local.bibliographicCitation.startpage275
local.contributor.affiliationMellor, Howard R., University of Oxford
local.contributor.affiliationCallaghan, Richard, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu5103268@anu.edu.au
local.contributor.authoruidCallaghan, Richard, u5103268
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060199 - Biochemistry and Cell Biology not elsewhere classified
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.absfor060112 - Structural Biology (incl. Macromolecular Modelling)
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.ariespublicationU3488905xPUB2623
local.identifier.citationvolume81
local.identifier.doi10.1159/000115967
local.identifier.scopusID2-s2.0-43449133278
local.identifier.uidSubmittedByU3488905
local.type.statusPublished Version

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