Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response
dc.contributor.author | Mellor, Howard R. | |
dc.contributor.author | Callaghan, Richard | |
dc.date.accessioned | 2015-12-13T22:17:37Z | |
dc.date.issued | 2008 | |
dc.date.updated | 2015-12-11T07:35:33Z | |
dc.description.abstract | Inherent and acquired resistance pathways account for the high rate of failure in cancer chemotherapy. The mechanisms or pathways mediating resistance may be classified as pharmacokinetic (i.e. alter intratumour drug exposue) or pharmacodynamic (i.e. failure to elicit cytotoxicity). More often than not, the resistant phenotype is characterised by alterations in multiple pathways. Consequently, the pathways may act synergistically or generate a broad spectrum of resistance to anticancer drugs. There has been a great deal of systematic characterisation of drug resistance in vitro. However, translating this greater understanding into clinical efficacy has rarely been achieved. This review explores the phenomenon of drug resistance in cancer and highlights the gap between in vitro and in vivo observations. This gap presents a major obstacle in overcoming drug resistance and restoring sensitivity to chemotherapy. | |
dc.identifier.issn | 0031-7012 | |
dc.identifier.uri | http://hdl.handle.net/1885/71240 | |
dc.publisher | S. Karger AG | |
dc.source | Pharmacology | |
dc.subject | Keywords: anthracycline; bleomycin; carboplatin; carmustine; cisplatin; cyclophosphamide; daunorubicin; dj 927; docetaxel; doxorubicin; elacridar; epirubicin; fluorouracil; gemcitabine; hycamptin; idarubicin; ifosfamide; irinotecan; lomeguatrib; methotrexate; mitom Anticancer drugs; Cancer chemotherapy; Drug resistance; Multidrug resistance; Pharmacodynamic resistance; Pharmacokinetic resistance | |
dc.title | Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response | |
dc.type | Journal article | |
local.bibliographicCitation.issue | 4 | |
local.bibliographicCitation.lastpage | 300 | |
local.bibliographicCitation.startpage | 275 | |
local.contributor.affiliation | Mellor, Howard R., University of Oxford | |
local.contributor.affiliation | Callaghan, Richard, College of Medicine, Biology and Environment, ANU | |
local.contributor.authoremail | u5103268@anu.edu.au | |
local.contributor.authoruid | Callaghan, Richard, u5103268 | |
local.description.embargo | 2037-12-31 | |
local.description.notes | Imported from ARIES | |
local.identifier.absfor | 060199 - Biochemistry and Cell Biology not elsewhere classified | |
local.identifier.absfor | 060110 - Receptors and Membrane Biology | |
local.identifier.absfor | 060112 - Structural Biology (incl. Macromolecular Modelling) | |
local.identifier.absseo | 970106 - Expanding Knowledge in the Biological Sciences | |
local.identifier.ariespublication | U3488905xPUB2623 | |
local.identifier.citationvolume | 81 | |
local.identifier.doi | 10.1159/000115967 | |
local.identifier.scopusID | 2-s2.0-43449133278 | |
local.identifier.uidSubmittedBy | U3488905 | |
local.type.status | Published Version |
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