TSPY, the cadidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X-implications for Y chromosome evolution

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dc.contributor.authorDelbridge, Margaret
dc.contributor.authorLongepied, Guy
dc.contributor.authorDepetris, Danielle
dc.contributor.authorMattei, Marle-Genevieve
dc.contributor.authorDisteche, Christine M
dc.contributor.authorGraves, Jennifer
dc.contributor.authorMitchell, Michael J
dc.date.accessioned2015-12-13T22:51:01Z
dc.date.available2015-12-13T22:51:01Z
dc.date.issued2004
dc.date.updated2015-12-11T10:43:27Z
dc.description.abstractTSPY, a candidate gene for a factor that promotes gonadoblastoma formation (GBY), is a testis-specific multicopy gene family in the male-specific region of the human Y (MSY) chromosome. Although it was originally proposed that male-specific genes on the Y originated from a transposed copy of an autosomal gene (Lahn & Page 1999b), at least two male-specific genes (RBMY and SRY) descended from a formerly recombining X-Y identical gene pair. Here we show that a TSPY homologue with similar gene structure lies in conserved positions, close to SMCX, on the X chromosome in human (TSPX) and mouse (Tspx). TSPX is widely expressed and subject to X inactivation. TSPX and TSPY therefore evolved from an identical gene pair on the original mammalian sex chromosomes. This supports the hypothesis that even male-specific genes on the Y chromosome may have their origin in ubiquitously expressed genes on the X. It also strengthens the case for TSPY as a candidate for GBY, since independent functional studies link TSPX to cell cycle regulation.
dc.identifier.issn0967-3849
dc.identifier.urihttp://hdl.handle.net/1885/81072
dc.publisherKluwer Academic Publishers
dc.sourceChromosome Research
dc.subjectKeywords: animal cell; article; cell cycle; chromosome inactivation; controlled study; gene; gene expression; gene structure; gonadoblastoma; human; human cell; mouse; multigene family; nonhuman; nucleotide sequence; priority journal; RBMY gene; sex chromosome; SRY evolution; TSPY; X chromosome; Y chromosome
dc.titleTSPY, the cadidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X-implications for Y chromosome evolution
dc.typeJournal article
local.bibliographicCitation.lastpage356
local.bibliographicCitation.startpage345
local.contributor.affiliationDelbridge, Margaret, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLongepied, Guy, INSERM
local.contributor.affiliationDepetris, Danielle, UNISERM
local.contributor.affiliationMattei, Marle-Genevieve, UNISERM
local.contributor.affiliationDisteche, Christine M, University of Washington
local.contributor.affiliationGraves, Jennifer, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMitchell, Michael J, UNISERM
local.contributor.authoremailu4021869@anu.edu.au
local.contributor.authoruidDelbridge, Margaret, u4025805
local.contributor.authoruidGraves, Jennifer, u4021869
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor060409 - Molecular Evolution
local.identifier.ariespublicationMigratedxPub9400
local.identifier.citationvolume12
local.identifier.doi10.1023/B:CHRO.0000034134.91243.1c
local.identifier.scopusID2-s2.0-3142701271
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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