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The marsupial retinocollicular system shows differential expression of messenger RNA encoding Eph receptors and their ligands during development

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dc.contributor.authorVidovic, Maria
dc.contributor.authorMarotte, Lauren
dc.contributor.authorMark, R F
dc.date.accessioned2015-12-13T23:35:00Z
dc.date.issued1999
dc.date.updated2015-12-12T09:38:19Z
dc.description.abstractThe protracted development of the wallaby (Macropus eugenii) has allowed study of messenger RNAs encoding Eph receptors EphA3 and EphA7 and ligands ephrin-A2 and -A5 in the retina and superior colliculus at intervals throughout the development of the retinocollicular projection: from birth, before retinal innervation, to postnatal day 95, when the projection is mature. Reverse transcription-polymerase chain reaction showed messenger RNAs for both receptors and ligands were expressed at all ages. EphA7 was expressed more highly in the rostral superior colliculus. Ephrin-A2 and -A5 were expressed more highly in the caudal colliculus. EphA3 was expressed in a complementary manner, more highly in temporal than in nasal retina. There are higher levels of expression of the ligands when the projection is only coarsely topographically organised. This suggests a role for them and their receptor EphA3 in this stage, by repulsive interactions which restrict temporal axens to rostral superior colliculus. This is the first account in a marsupial mammal of the appearance of this molecular family, substantiating its ubiquitous role in topographically organised neuronal connections. Nevertheless, expression is not the same as in the mouse, suggesting differences in the details of topographic coding between species.
dc.identifier.issn0360-4012
dc.identifier.urihttp://hdl.handle.net/1885/93713
dc.publisherWiley-Liss Inc
dc.sourceJournal of Neuroscience Research
dc.subjectKeywords: animal tissue; article; marsupial; nerve projection; nonhuman; polymerase chain reaction; priority journal; superior colliculus; visual system; Animals; Brain Chemistry; Ephrin-A2; Ephrin-A3; Gene Expression Regulation, Developmental; Gene Expression Regu Development; Ephrins; Mammalian visual system; Reverse transcription-polymerase chain reaction; Topographic connections
dc.titleThe marsupial retinocollicular system shows differential expression of messenger RNA encoding Eph receptors and their ligands during development
dc.typeJournal article
local.bibliographicCitation.lastpage254
local.bibliographicCitation.startpage244
local.contributor.affiliationVidovic, Maria, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMarotte, Lauren, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMark, R F, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu8501165@anu.edu.au
local.contributor.authoruidVidovic, Maria, u8501165
local.contributor.authoruidMarotte, Lauren, u7400435
local.contributor.authoruidMark, R F, u750004
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030499 - Medicinal and Biomolecular Chemistry not elsewhere classified
local.identifier.ariespublicationMigratedxPub25107
local.identifier.citationvolume57
local.identifier.doi10.1002/(SICI)1097-4547(19990715)57:2<244::AID-JNR10>3.0.CO;2-D
local.identifier.scopusID2-s2.0-0033566337
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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