Treatment of mice with fenbendazole attenuates allergic airways inflammation and Th2 cytokine production in a model of asthma

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dc.contributor.authorCai, Yeping
dc.contributor.authorZhou, Jiansheng
dc.contributor.authorWebb, Dianne
dc.date.accessioned2015-12-08T22:23:01Z
dc.date.issued2009
dc.date.updated2016-02-24T11:38:16Z
dc.description.abstractMouse models have provided a significant insight into the role of T-helper (Th) 2 cytokines such as IL-5 and IL-13 in regulating eosinophilia and other key features of asthma. However, the validity of these models can be compromised by inadvertent infection of experimental mouse colonies with pathogens such as oxyurid parasites (pinworms). While the benzimidazole derivative, fenbendazole (FBZ), is commonly used to treat such outbreaks, the effects of FBZ on mouse models of Th2 disease are largely unknown. In this investigation, we show that mice fed FBZ-supplemented food during the in utero and post-weaning period developed attenuated lung eosinophilia, antigen-specific IgG1 and Th2 cytokine responses in a model of asthma. Treatment of the mediastinal lymph node cells from allergic mice with FBZ in vitro attenuated cell proliferation, IL-5 and IL-13 production and expression of the early lymphocyte activation marker, CD69 on CD4+ T cells and CD19+ B cells. In addition, eosinophilia and Th2 responses remained attenuated after a 4-week withholding period in allergic mice treated preweaning with FBZ. Thus, FBZ modulates the amplitude of Th2 responses both in vivo and in vitro.
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/1885/32698
dc.publisherBlackwell Publishing Ltd
dc.sourceImmunology and Cell Biology
dc.subjectKeywords: CD69 antigen; fenbendazole; immunoglobulin G1; interleukin 13; interleukin 5; animal cell; animal experiment; animal model; animal tissue; antigen expression; article; asthma; B lymphocyte; CD4+ T lymphocyte; cell proliferation; controlled study; cytokine Allergy; Anthelmintics; Eosinophils; Th2 cytokines
dc.titleTreatment of mice with fenbendazole attenuates allergic airways inflammation and Th2 cytokine production in a model of asthma
dc.typeJournal article
local.bibliographicCitation.issue8
local.bibliographicCitation.lastpage629
local.bibliographicCitation.startpage623
local.contributor.affiliationCai, Yeping, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationZhou, Jiansheng, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWebb, Dianne, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu4029322@anu.edu.au
local.contributor.authoruidCai, Yeping, u4029322
local.contributor.authoruidZhou, Jiansheng, u4032064
local.contributor.authoruidWebb, Dianne, u7700747
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor110701 - Allergy
local.identifier.ariespublicationu6800332xPUB94
local.identifier.citationvolume87
local.identifier.doi10.1038/icb.2009.47
local.identifier.scopusID2-s2.0-70450277312
local.identifier.thomsonID000272144600011
local.identifier.uidSubmittedByu6800332
local.type.statusPublished Version

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