Synthesis of spiroisoxazolines through cycloadditions of nitrile oxides with 3-methylenequinuclidine
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Lee, Connie
Easton, Christopher
Savage, G Paul
Simpson, Gregory Wayne
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ARKAT Foundation
Abstract
Four spiroisoxazolines have been prepared, by cycloaddition of aceto-, pivalo-, benzo- and mesito-nitrile oxide with 3-methylenequinuclidine. The reactions were completely regioselective, within the limits of detection. None of the isoxazolines showed significant inhibition of acetylcholinesterase.
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ARKIVOC
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2037-12-31
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