Polymorphism- and Species-Dependent Inactivation of Glutathione Transferase Zeta by Dichloroacetate
Date
2000
Authors
Tzeng, Huey-Fen
Blackburn, Anneke
Board, Philip
Anders, Michael
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
Glutathione transferase zeta catalyzes the glutathione-dependent oxidation or conjugation of a range of α-haloacids. Repeated administration of dichloroacetate to human subjects increases its plasma elimination half- life, and the activity of glutathione
Description
Keywords
Keywords: acetic acid derivative; dichloroacetic acid; glutathione transferase; animal tissue; article; biotransformation; catalysis; enzyme inactivation; enzyme kinetics; enzyme polymorphism; human; human tissue; minimum inhibitory concentration; mouse; nonhuman;
Citation
Collections
Source
Chemical Research in Toxicology
Type
Journal article
Book Title
Entity type
Access Statement
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DOI
10.1021/tx990175q
Restricted until
2037-12-31