Exhaustion of Type I interferon response following an acute viral infection
Date
2006
Authors
Alsharifi, Mohammed
Regner, Matthias
Blanden, Robert
Lobigs, Mario
Lee, Eva
Koskinen, Aulikki
Mullbacher, Arno
Journal Title
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Volume Title
Publisher
American Association of Immunologists
Abstract
Viral infections often cause a period of heightened susceptibility to a secondary infection but the cause of this phenomenon is unknown. We found that a primary viral infection in mice rapidly triggers an IFN-I-dependent partial activation state in the majority of B and T lymphocytes, which reverts to a resting phenotype within 5 days. When a secondary infection with an unrelated virus occurred 5 to 9 days after the primary infection, no recurrence of marked activation of lymphocytes was observed. This was not due to an inherent inability of the previously activated cells to undergo renewed partial activation, because they responded when challenged with virus after transfer into "naive" recipients. Instead, the failure to respond optimally resided in the original host's incapacity to mount an IFN-I response to the secondary infection during this time period. Thus, transient immunosuppression through exhaustion of IFN-I production during an acute viral infection creates a time period of enhanced susceptibility to secondary infection.
Description
Keywords
Keywords: alpha interferon; CD45 antigen; glycoprotein p 15095; animal cell; animal experiment; animal model; animal tissue; article; B lymphocyte; controlled study; cytokine production; female; immune deficiency; infection sensitivity; lymphocyte activation; mouse
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Source
Journal of Immunology
Type
Journal article
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2037-12-31