4-Alkoxycarbonyl- and aminocarbonyl-substituted isoxazoles as masked acrylates and acrylamides in the asymmetric synthesis of Δ 2 -isoxazolines
Date
2006
Authors
Lee, Connie
Herlt, Anthony
Simpson, Gregory Wayne
Willis, Anthony
Easton, Christopher
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
4-Alkoxycarbonyl and aminocarbonyl-substituted isoxazoles undergo conjugate reduction to give Δ2-isoxazolines on treatment with sodium borohydride and sodium trifluoroacetoxyborohydride, respectively. They are also alkylated at C5 through sonication with
Description
Keywords
Keywords: Acrylamides; Soxazolines; Tertiary alkyl iodides; Alkylation; Reaction kinetics; Reduction; Sodium compounds; Substitution reactions; Synthesis (chemical); Organic compounds; acrylamide derivative; acrylic acid derivative; aminocarbonyl derivative; carbon
Citation
Collections
Source
Journal of Organic Chemistry
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
Restricted until
2037-12-31
Downloads
File
Description