Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation

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Zabala, Angelica O.
Xu, Wei
Chooi, Yit-Heng
Tang, Yi

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Elsevier

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Azaphilones are a class of fungal metabolites characterized by a highly oxygenated pyrano-quinone bicyclic core and exhibiting a broad range of bioactivities. Although widespread among various fungi, their biosynthesis has not been thoroughly elucidated.

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Chemistry and Biology

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2037-12-31