Carboxymethylated-κ-casein: a convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation

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Carver, John
Duggan, Peter J
Ecroyd, Heath
Liu, Yanqin
Meyer, Adam G
Tranberg, Elisabet

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Pergamon-Elsevier Ltd

Abstract

Reduced and carboxymethylated-κ-casein (RCM-κ-CN) is a milk-derived amyloidogenic protein that readily undergoes nucleation-dependent aggregation and amyloid fibril formation via a similar pathway to disease-specific amyloidogenic peptides like amyloid

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Bioorganic and Medicinal Chemistry

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2037-12-31