Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning
-
Altmetric Citations
Jackson, Colin; Carville, Angela; Ward, Jeanine; Mansfield, Keith; Ollis, David; Khurana, Tejvir; Bird, Steven
Description
Organophosphorus (OP) pesticides are a diverse class of acetylcholinesterase (AChE) inhibitors that are responsible for tremendous morbidity and mortality worldwide, killing approximately 300,000 people annually. Enzymatic hydrolysis of OPs is a potential therapy for acute poisoning. OpdA, an OP hydrolase isolated from Agrobacterium radiobacter, has been shown to decrease lethality in rodent models of OP poisoning. This study investigated the effects of OpdA on AChE activity, plasma...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2014 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/62906 |
Source: | Toxicology |
DOI: | 10.1016/j.tox.2014.01.003 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Jackson_Use_of_OpdA,_an_2014.pdf | 482.2 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator