A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration
Date
2009
Authors
Chu, Jessie
Hong, Nancy A
Masuda, Claudio A.
Jenkins, Brian V.
Nelms, Keats
Goodnow, Christopher
Glynne, Richard
Wu, Hua
Masliah, Eliezer
Joazeiro, Claudio A.P.
Journal Title
Journal ISSN
Volume Title
Publisher
National Academy of Sciences (USA)
Abstract
A mouse neurological mutant, lister, was identified through a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Homozygous lister mice exhibit profound early-onset and progressive neurological and motor dysfunction. lister encodes a RING finger
Description
Keywords
Keywords: protein listerin; ubiquitin protein ligase E3; unclassified drug; animal experiment; animal model; animal tissue; article; controlled study; genetic analysis; male; mouse; nerve degeneration; nonhuman; phenotypic variation; priority journal; protein analy
Citation
Collections
Source
PNAS - Proceedings of the National Academy of Sciences of the United States of America
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
DOI
10.1073/pnas.0812819106
Restricted until
2037-12-31