T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma
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Gong, Fang; Zheng, Ting; Zhou, Pengcheng
Description
For many decades, T helper 2 (TH2) cells have been considered to predominantly regulate the pathogenic manifestations of allergic asthma, such as IgE-mediated sensitization, airway hyperresponsiveness, and eosinophil infiltration. However, recent discoveries have significantly shifted our understanding of asthma from a simple TH2 cell-dependent disease to a heterogeneous disease regulated by multiple T cell subsets, including T follicular helper (TFH) cells. TFH cells, which are a...[Show more]
Collections | ANU Research Publications |
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Date published: | 2019 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/286481 |
Source: | Frontiers in Immunology |
DOI: | 10.3389/fimmu.2019.02918 |
Access Rights: | Open Access |
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fimmu-10-02918.pdf | 1.26 MB | Adobe PDF |
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