The Two-Faced Nature of Small Heat-Shock Proteins: Amyloid Fibril Assembly and the Inhibition of Fibril Formation. Relevance to Disease States

Abstract

The ability of small heat-shock proteins (sHsps) such as αB-crystallin to inhibit the amorphous (disordered) aggregation of varied target proteins in a chaperone-like manner has been well described. The mechanistic details of this action are not understo Show more