Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

A Homogeneous Nickel Catalyst for Reductive Amination of γ-Keto Acids using Hydrogen

Simple item page
dc.contributor.authorChakrabortty, Soumyadeepen
dc.contributor.authorMoritz, Jan Oleen
dc.contributor.authorKallmeier, Fabianen
dc.contributor.authorNeumann, Helfrieden
dc.contributor.authorTin, Sergeyen
dc.contributor.authorBeller, Matthiasen
dc.contributor.authorde Vries, Johannes G.en
dc.date.accessioned2026-07-05T22:42:16Z
dc.date.available2026-07-05T22:42:16Z
dc.date.issued2024-11-25en
dc.description.abstractThe reductive amination of levulinic and 2-acetyl benzoic acids with hydrogen and various amines proceeds efficiently in the presence of a homogeneous Ni/triphos-catalyst. The reaction rate of the overall process is significantly enhanced using 3,3,3-trifluoroethanol (TFE) as solvent. The optimized synthetic protocol allows for a straightforward access of >20 examples of N-functionalized pyrrolidinones in high yields (75 % and >99 %). Upscaling to 10 mmol-scale is demonstrated and mechanistic in situ studies revealed the presence of alkoxy- and hydroxylactams as crucial intermediates.en
dc.description.sponsorshipWe thank the Deutsche Forschungsgemeinschaft (DFG) for financial support (project number 411421782). We also want to thank the Leibniz Association's strategic networking program Leibniz ScienceCampus ComBioCat for funding. The authors thank Prof. Eszter Baráth for some use of the facilities. Open Access funding enabled and organized by Projekt DEAL.en
dc.description.statusPeer-revieweden
dc.format.extent7en
dc.identifier.issn1867-3880en
dc.identifier.otherORCID:/0000-0001-7073-2766/work/219173128en
dc.identifier.scopus85205056181en
dc.identifier.urihttps://hdl.handle.net/1885/733813006
dc.language.isoenen
dc.provenanceCC BY-NC-NDen
dc.rights© 2024 The Authors.en
dc.sourceChemCatChemen
dc.subjectAlkoxy lactamen
dc.subjectLevulinic aciden
dc.subjectNickelen
dc.subjectReductive aminationen
dc.subjectTriphosen
dc.titleA Homogeneous Nickel Catalyst for Reductive Amination of γ-Keto Acids using Hydrogenen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.contributor.affiliationChakrabortty, Soumyadeep; Leibniz Institute for Catalysisen
local.contributor.affiliationMoritz, Jan Ole; Leibniz Institute for Catalysisen
local.contributor.affiliationKallmeier, Fabian; Leibniz Institute for Catalysisen
local.contributor.affiliationNeumann, Helfried; Leibniz Institute for Catalysisen
local.contributor.affiliationTin, Sergey; Leibniz Institute for Catalysisen
local.contributor.affiliationBeller, Matthias; Leibniz Institute for Catalysisen
local.contributor.affiliationde Vries, Johannes G.; Leibniz Institute for Catalysisen
local.identifier.citationvolume16en
local.identifier.doi10.1002/cctc.202400987en
local.identifier.pureda65505f-2a67-4427-9914-52549860f851en
local.identifier.urlhttps://www.scopus.com/pages/publications/85205056181en
local.type.statusPublisheden

Downloads

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
A_Homogeneous_Nickel_Catalyst.pdf
Size:
12.07 MB
Format:
Adobe Portable Document Format
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2026 LYRASIS

abcd