The evolution of epigenetic regulators CTCF and BORIS/CTCFL in amniotes
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Hore, Tim; Deakin, Janine; Graves, Jennifer
Description
CTCF is an essential, ubiquitously expressed DNA-binding protein responsible for insulator function, nuclear architecture, and transcriptional control within vertebrates. The gene CTCF was proposed to have duplicated in early mammals, giving rise to a paralogue called “brother of regulator of imprinted sites” (BORIS or CTCFL) with DNA binding capabilities similar to CTCF, but testis-specific expression in humans and mice. CTCF and BORIS have opposite regulatory effects on human cancer-testis...[Show more]
Collections | ANU Research Publications |
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Date published: | 2008-08-25 |
Type: | Journal article |
URI: | http://hdl.handle.net/10440/452 http://digitalcollections.anu.edu.au/handle/10440/452 |
Source: | PLoS Genetics |
DOI: | 10.1371/journal.pgen.1000169 |
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Hore_Evolution2008.pdf | 964.11 kB | Adobe PDF |
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