Origin and evolution of candidate mental retardation genes on the human X chromosome (MRX)
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Delbridge, Margaret; McMillan, Daniel; Doherty, Ruth; Deakin, Janine; Graves, Jennifer
Description
BACKGROUND: The human X chromosome has a biased gene content. One group of genes that is over-represented on the human X are those expressed in the brain, explaining the large number of sex-linked mental retardation (MRX) syndromes. RESULTS: To determine if MRX genes were recruited to the X, or whether their brain-specific functions were acquired after relocation to the mammalian X chromosome, we examined the location and expression of their orthologues in marsupials, which diverged from...[Show more]
Collections | ANU Research Publications |
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Date published: | 2008-02-05 |
Type: | Journal article |
URI: | http://hdl.handle.net/10440/243 http://digitalcollections.anu.edu.au/handle/10440/243 |
Source: | BMC Genomics |
DOI: | 10.1186/1471-2164-9-65 |
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Delbridge_Origin2008.pdf | 687.16 kB | Adobe PDF |
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